ceesdekker.net for Dummies
ceesdekker.net for Dummies
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Rotary movement of DNA rotors on nanopores. Best row: Uncooked video clip in the Cy5 channel of each and every rotor. Middle row: corresponding one-particle localization benefits of each finishes from the DNA rotors. The situation of the current body is marked as orange and blue dots, and also the trajectory of The ten frames prior to The existing frame is demonstrated as strong strains.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
‘It had been merely a matter of finding up a e book on cell biology and beginning to read through. I had originate from a earth of ultra-high vacuums, cryostats and quantum phenomena, and now I had been Functioning at room temperature with molecular biology kits.
Given that 2000, Dekker has shifted the leading focus of his get the job done toward biophysics wherever he scientific studies the Houses of one biomolecules and cells utilizing the tools of nanotechnology. This variation of subject was pushed by his fascination to the extraordinary functioning of biological molecular constructions, together with by the lengthy-phrase point of view a large number of fascinating discoveries could be predicted With this subject.[five] Present-day strains of study in his biophysics group are within the regions of:[6]
2015, discovery that condensin is actually a extremely adaptable protein construction; and initial detection of DNA knots applying nanopores
Instance (three) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is demonstrated in grey, the rim of the pore is highlighted in purple, as well as a 3D rendering from the movement with the DNA rod is shown.
Length control of individual carbon nanotubes by nanostructuring with the scanning tunneling microscope
Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim with the pore is highlighted in pink, along with a 3D rendering on the motion of your DNA rod is displayed.
In 1993, as a younger and keen affiliate professor at Delft University of Engineering, I'd initially targeted the investigation attempts of https://www.ceesdekker.net my team on measuring the electrical conductance of just one conducting-polymer molecule. In two decades, we had produced a device where only one wire of a phthalocyaninepolysiloxane polymer was connected among two carefully spaced metallic nanoelectrodes.
It had been through this era that Dekker performed research on magnetic spin methods and on sound in superconductors and semiconductors.
Testing pseudotopological and nontopological designs for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
Nanoscientist Cees Dekker is definitely an amiable and flamboyant person who appears much young compared to sixty two several years he really is – modern glasses, psychedelic shirt, partaking smile – but not a person to waste time. He takes his time, but not more than necessary.
2008, initially observation of protein-coated DNA translocation by means of nanopores; settled the origin of the electrophoretic drive on DNA in nanopores; uncovered a major velocity improve of microtubules in electric powered fields; learned an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid
2004, discovery of recent physics in translocation of DNA by means of nanopores; to start with experimental examine of ions conduction in nanofluidic channels; first electrochemistry with specific single-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; to start with electrical docking of microtubules on kinesin-coated nanostructures; 1st biophysics characterization of the mechanical Homes of double-stranded RNA; and to start with single-molecule review of DNA translocation by a restriction-modification enzyme.